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Concanamycin A

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Formula: C46H75NO14
CAS: 80890-47-7
search Element: concanamycin
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Identification

Structural Formula
Concanamycin A
CAS:
80890-47-7
EINECS:
Molecular Formula:
C46H75NO14
MDL:
MFCD00210037
SMILES:
CCC1C(C(C/C(=C/C=C/C(C(OC(=O)/C(=C/C(=C/C(C1O)C)/C)/OC)C(C)C(C(C)[C@@]2(C[C@H]([C@@H](C(O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
Synonym:
nsc 674620 ; x4357b ; antibioticx4357b ; antibiotic a661i ; folimycin ; concanamycin a ; a,concanamycin ; oxacyclooctadeca-3,5,13,15-tetraen-2-one,18- [(1s,2r,3s)-3-[(2r,4r,5s,6r)-4-[[4-o- (aminocarbonyl)-2,6-dideoxy-â ; -d-arabinohexopyranosyl] oxy]tetrahydro-2-hydroxy-5- methyl-6-(1e)-1-propenyl-2h-pyran-2-yl]- 2-hydroxy-1-methylbutyl]-9-ethyl-8,10- dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-,(3z,5e,7r,8r,9s,10s,11r,13e,15e,- 17s,18r)- ; a661-i ; antibiotic s-45a ; s-45a


Description

Concanamycin A, also designated folimycin, is an antibiotic and well-noted specific inhibitor of V-ATPase (vacuolar type H+-ATPase) activity. Concanamycin A is also capable of inducing cell-death through apoptosis, able to inhibit perforin-based cytotoxic activity in CD8+ T cells, and to inhibit intracellular protein trafficking in both plant and animal cells. As an inhibitor of V-ATPase, concanamycin has been reported to induce cell death via apoptosis in WEHI 231, SP2/0-Ag14 cells lines as well as mouse hybridomas. The inhibition of perforin-based cytotoxic activity in CD8+ CTL clone OE4 was reported to be selective for completely blocking perforin-based cytotoxic activity in these clones. Additionally, concanamycin A was noted to lead to reversible vacuolation of the Golgi apparatus in tobacco BY-2 cells, indicating potential interference with protein trafficking in this cell line.


Suppliers

Leap Chem Co., Ltd
LC5041512
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Santa Cruz Biotechnology, Inc.
202111
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Properties for Concanamycin A

Molecular Weight:
866.086 g·mol−1
Density:
1.2 g/cm3
Melting point:
179-180°C (dichloromethane ethanol )
Boiling point:
966.4°C at 760 mmHg
Flash point:
538.3°C
Solubility:
Soluble in water (partly), chloroform, ethanol, methanol, and DMSO.
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Safety & Transport Information

Risk Codes:
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
T+
Hazard symbol T+
Storage temperature :
-20°C
RID/ADR certification :
UN 3462 6.1 / PG 2
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Alternative Distributors of [Concanamycin A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH

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Mol File:
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MSDS:
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