Clofarabine | CAS 123318-82-1 | Chemical-Suppliers

Element: clofarabine

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C-S » Chemicals » clofarabine-PX15087

Identification

Clofarabine

CAS:

123318-82-1

EINECS:

Molecular Formula:

C₁₀H₁₁ClFN₅O₃

MDL:

MFCD00871077

SMILES:

C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)F)N=C(N=C2N)Cl

Synonym:

clolar ; clofarabine, free base ; clofarabine ; clofarabine(forr&donly) ; clorfarabine ; cafda ; clola ; clofarex ; 200mg ; evoltra

Description

Clofarabine is a purine nucleoside analogue that is a lipophilic derivative of 2-Chloro-2'-deoxyadenosine. The advantage to using this compound compared to 2-Chloro-2'-deoxyadenosine is the increased stability of the acid. Studies suggest that Clofarabine contains the best qualities of Fludarabine and 2-Chloro-2'-deoxyadenosine, with increased resistance to deamination and phosphorolysis. The compound functions by inhibiting intracellular ribonucleotide reductase and DNA polymerase, which suppresses DNA replication. Furthermore, Clofarabine displays greater affinity towards dCK (deoxycytidine kinase, dCyd), an enzyme essential in nucleoside phosphorylation.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

Wuhan PharmChem Co., LTD.

WP275825

Chemlyte Solutions

CS198594

Aozeal Certified Standards (AOCS), Inc.

C0147.00

Guangzhou Topwork Chemical Co., Ltd.

GTC3961584

General Intermediates of Canada, Inc.

GIOC4072035

Evonik ( formerly Wilshire Technologies, Inc. )

E5282112

Xiamen Equation Chemical Co.,Ltd

XECC3521760

Aecochem Corp.

AC154462

CSNpharm, Inc.

CSN16701

Hangzhou Lingrui Chemical Co., Ltd.

HLC3851540

Finetech Industry Limited

FIL2751100

Pharmacore Co., Limited

PL253759

Acinopeptide Co., Ltd.

A242484

AK Scientific, Inc.

AS209627

Simagchem Corporation

SC231693

Xingrui Industry Co., Limited

XIL3191276

Amadis Chemical Company Limited

ACCL3411705

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

278864

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+%

Alfa (A Johnson Matthey Company)

A480014400

Clofarabine (2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine, Clolar)

United States Biological

C5843-55

(2R,3R,4S,5R)-5-(6-Amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol

BLD Pharmatech Ltd

BP2736082080

Prices & Availability

Data is processed

Properties for Clofarabine

Molecular Weight:

303.68 g·mol−1

Density:

2.12 g/cm³ (Predicted)

Melting point:

228-2310C

Boiling point:

599.52° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (10 mM), DMSO (61 mg/mL), and ethanol (10 mM).

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed

Safety Codes:

S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Symbols:

Storage temperature :

Desiccate at +4°C

Alternative Distributors of [Clofarabine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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Clofarabine (2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine, Clolar)