clasto-Lactacystin β-lactone, a synthetic derivative of lactahydrin, is a cell permeable, irreversible and specific inhibitor of the 20S proteasome involved in the ubiquitin-proteasome degradation pathway. Kinetic studies indicate that clasto-Lactacystin β-lactone interacts with the proteasome at its catalytic site threonines, which opens the β-lactone ring and allows the proteasome's catalytic hydroxyl group to become acylated. clasto-Lactacystin β-lactone has been reported to rapidly enter cells in mammalian cell culture media and to additionally inactivate the proteasome in Jurkat cells in a dose-dependent manner. In addition, clasto-Lactacystin β-lactone is reported to inhibit cathepsin A, lead to adipogenesis and induce neurite growth in rat PC12 cells.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R37/38 - Irritating to respiratory system and skin R41 - Risk of serious damage to eyes
Safety Codes:
S16 - Keep away from sources of ignition - No smoking S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Storage temperature :
-20°C
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Alternative Distributors of [clasto-Lactacystin β-lactone]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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