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Chromomycin A3

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Formula: C57H82 O26
CAS: 7059-24-7
search Element: chromomycin
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Identification

Structural Formula
Chromomycin A3
CAS:
7059-24-7
EINECS:
Molecular Formula:
C57H82 O26
MDL:
MFCD00043151
SMILES:
CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O
Synonym:
chromomycin ; 3)-2,6-dideoxy-b-d-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-o-methyl-,(1s)- ; nsc-58514 ; antibioticb599 ; cma3 ; toyomycin ; olivomycin d, 3d-o-(4-o-acetyl-2,6-dideoxy-3-c-methyl-a-l-arabino-hexopyranosyl)-7-methyl- ; chromoycin a3 ; aburamycin b ; aburamycin beta ; nsc 58514 ; chromomycina3 (8ci) ; chromomycin a3 ; d-threo-2-pentulose,1-c-[(2s,3s)-7-[[4-o-acetyl-2,6-dideoxy-3-o-(2,6-dideoxy-4-o-methyl-a-d-lyxo-hexopyranosyl)-b-d-lyxo-hexopyranosyl]oxy]-3-[[o-4-o-acetyl-2,6-dideoxy-3-c-methyl-a-l-arabino-hexopyranosyl-(1® ; aburamycinb ; 3)-o-2,6-dideoxy-b-d-arabino-hexopyranosyl-(1® ; olivomycin d ; antibiotic69895a ; antibiotic b 599


Description

Chromomycin A3, a fluorescent DNA stain and antibiotic, has been reported to strongly inhibit zinc-dependent transcriptional activity of sheep Metallothionein 1A promoter in reporter gene assays of transfected cells. This compound has also been shown to be a potent inhibitor of neuronal apoptosis induced by glutathione depletion-induced oxidative stress and DNA-damaging agent Camptothecin. Mechanistic studies suggest that Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.


Suppliers

Shandong Ench Chemical Co.,Ltd
SECC8404200
+
Indofine Chemical Co, Inc.
Bio-730
A.G. Scientific
AS4201260
Iris Biotech GmbH
LS-1018.0000
+
Xingrui Industry Co., Limited
XIL8123248
+
Santa Cruz Biotechnology, Inc.
200907
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CAS equal suppliers

Toyomycin
Iris Biotech GmbH
LS-1018
Chromomycin A3, 97%
Alfa (A Johnson Matthey Company)
A12163648

Prices & Availability




Data is processed


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Properties for Chromomycin A3

Molecular Weight:
1183.39 g·mol−1
Density:
1.47 g/cm3
Melting point:
182.8-185° C
Boiling point:
1177.42° C at 760 mmHg
Solubility:
Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
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Safety & Transport Information

A deadly poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
Risk Codes:
R28 - Very toxic if swallowed
R61 - May cause harm to the unborn child
Safety Codes:
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Classes:
6.1(a)
Hazard Symbols:
T+, T
Hazard symbol T Hazard symbol T+
Storage temperature :
2-8°C
RID/ADR certification :
UN 3462 6.1 / PG 1
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Alternative Distributors of [Chromomycin A3]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | Fermentek Ltd.

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MSDS:
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