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Chromeceptin

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Formula: C19H16 F3 N3 O
CAS: 331859-86-0
search Element: chromeceptin

Identification

Structural Formula
Chromeceptin
CAS:
331859-86-0
EINECS:
Molecular Formula:
C19H16 F3 N3 O
MDL:
MFCD00815850
SMILES:
CN(C)C1=CC2=C(C=C1)C(C(=C(O2)N)C#N)C3=CC(=CC=C3)C(F)(F)F
Synonym:
2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene ; Chromeceptin ; 4H-1-Benzopyran-3-carbonitrile,2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-


Description

Chromeceptin is a cell-permeable benzochromene compound that blocks insulin-induced adipogenesis in 3T3-L1 cells (100% blockage at ≤ 20 ng/μl) and selectively suppresses IGF2- (insulin-like growth factor 2) dependent growth of HepG2 carcinoma cells (IC50 = 29 nM). Chromeceptin has been shown to bind to MFP-2 (multifunctional protein-2) and activate STAT6-mediated gene expression, such as IGFBP-1 and SOCS-3, in HepG2 cells.


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Properties for Chromeceptin

Molecular Weight:
359.349 g·mol−1
Density:
~1.4 g/cm3 (Predicted)
Melting point:
189.05° C (Predicted)
Boiling point:
~497.2° C at 760 mmHg (Predicted)
Solubility:
Soluble in water (<2 mg/ml), DMSO (>20 mg/ml), and methanol (100 mg/ml).
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [Chromeceptin]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Mol File:
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MSDS:
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