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8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate triethylammonium salt

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Formula: C16H15 Cl N5 O7 P S
CAS: 54364-02-2

Identification

Structural Formula
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate triethylammonium salt
CAS:
54364-02-2
EINECS:
Molecular Formula:
C16H15 Cl N5 O7 P S
MDL:
SMILES:
CCN(CC)CC.C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=O)(O1)O
Synonym:
guanosine-3'-5'-cyclic monophosphate, 8-(4-chlorophenylthio)-, triethylammonium salt ; 8-pcpt-cgmp, tea ; 4h-furo[3,2-d]-1,3,2-dioxaphosphorin,guanosine deriv. ; 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate triethylammonium salt ; guanosine,8-[(4-chlorophenyl)thio]-, cyclic 3',5'-(hydrogen phosphate) ; cgmp, 8-pcpt-, tea ; 8-((4-chlorophenyl)thio)cyclic-3',5'-gmp ; 8-(p-chlorophenylthio)-cgmp ; 8-(4-chlorophenylthio)-cgmp


Description

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate triethylammonium salt (8-pCPT-cGMP • TEA) is a selective activator of cGMP-dependent protein kinase Iα, Iβ and type II as well as of cGMP-gated ion channels. The compound has a higher activation potential as compared to cGMP, the compound displays excellent cell membrane permeability and phosphodiesterase stability. 8-pCPT-cGMP • TEA has been preferred alternative to situations where dibutyryl-cGMP has been found to be an unsuitable analog.


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Properties for 8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate triethylammonium salt

Molecular Weight:
589 g·mol−1
Solubility:
Soluble in water.
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