8-(4-chlorophenylthio)guanosine*3':5'-cyclicmono ; 8-(4-chlorophenylthio)guanosine-3',5'-cyclicmonophosphate(8-pcpt-cgmp),sodiumsalt ; 8-(4-CHLOROPHENYLTHIO)GUANOSINE 3':5'-CYLIC MONOPHOSPHATE SODIUM SALT ; 8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT ; 8-PCPT-CGMP NA ; 8-PCPT-CGMP SODIUM SALT ; 8-PCPT-CGMP TEA ; CGMP, 8-PCPT-, NA
Description
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt (8-CPT-2'-O-Me-cAMP• Na ) is a selective activator of cGKI α, cGKI β, and cGKII (cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II )as well as of CNG (cGMP-gated ion channels). The compounds higher activation potential as compared to cGMP, and retains excellent cell membrane permeability and phosphodiesterase stability. 8-CPT-2'-O-Me-cAMP • Na has been preferred alternative to unsuitable analogs such as dibutyryl-cGMP.