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8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt

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Formula: C10H10ClN5O6P.Na
CAS: 41941-56-4
search Element: chloroadenosine monophosphate cyclic sodium salt
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Identification

Structural Formula
8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt
CAS:
41941-56-4
EINECS:
Molecular Formula:
C10H10ClN5O6P.Na
MDL:
MFCD01076560
SMILES:
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=NC=N4)N)N=C3Cl)O)OP(=O)(O1)[O-].[Na+]
Synonym:
8-chloroadenosine,3',5'-cyclicphosphate ; nsc614491 ; 8-chloroadenosine 3',5'-monophosphate ; 8-chloro-cyclicadenosinemonophosphate ; 8-chloro-camp ; ccris 846 ; 8-chlorocyclicamp ; ncs 614491 ; tocladesine ; 8-cl-camp


Description

8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt is a site-selective cAMP analog that inhibits various cancer cell lines such as HT29 colorectal cells and ZR-75-1 breast carcinoma, which is due to selective activation of PKA (protein kinase A) isoenzymes. Studies show that 8-Chloroadenosine 3',5'-Cyclic Monophosphate down-regulates the RI α subunit and up-regulates the RII β subunit of cAMP-dependent protein kinases leading to type II holoenzyme-dependent growth inhibition of caner cells such as HL-60. In addition, it is suggested that 8-Chloroadenosine 3',5'-Cyclic Monophosphate can possibly stimulate the antitumor effect of taxanes at micromolar concentrations. Further studies show that mdr-1 mRNA expression is reduced greatly in the presence of 8-Chloroadenosine 3',5'-Cyclic Monophosphate.


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Santa Cruz Biotechnology, Inc.
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Properties for 8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt

Molecular Weight:
363.65 g·mol−1
Solubility:
aqueous base: soluble
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [8-Chloroadenosine 3',5'-Cyclic Monophosphate sodium salt]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Haohua Industry Co., Ltd.

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