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8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide monohydrochloride

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Formula: C22H19ClN4O3.HCl
CAS: 146033-02-5

Identification

Structural Formula
8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide monohydrochloride
CAS:
146033-02-5
EINECS:
Molecular Formula:
C22H19ClN4O3.HCl
MDL:
MFCD17215974
SMILES:
C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl
Synonym:


Description

SC-51089 is a selective antagonist of prostaglandin E2, which displays specificity towards the EP1 receptor subtype. Studies indicate that SC-51089 can induce nociceptive behaviors in rats as a result of its antagonistic effects on prostaglandin E2. This compound contains a diacylhydrazine moiety, which has often been observed to release hydrazine. Alternate studies suggest that SC-51089 can be metabolized by rat and human hepatocytes, however different metabolic products are produced. For instance, SC-51089 undergoes aromatic hydroxylation with consequent glucuronidation and sulphation in human hepatocytes, while oxidative N-dealkylation with opening of the oxazepine ring and consequent glucuronidation in observed in rat hepatocytes. SC-51089 is an inhibitor of EP2 and EP3.


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Santa Cruz Biotechnology, Inc.
201344
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SC-51089
Santa Cruz Biotechnology, Inc.
sc-201344

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Properties for 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide monohydrochloride

Molecular Weight:
459.33 g·mol−1
Melting point:
162-164° C
Boiling point:
633° C at 760 mmHg
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