Sp-8-Br-cGMPS | CAS 153660-03-8 | Chemical-Suppliers

Element: cgmps

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C-S » Chemicals » cgmps-PX77170

Identification

Sp-8-Br-cGMPS

CAS:

153660-03-8

EINECS:

Molecular Formula:

C₁₀H₁₁ Br N₅ O₆ P S

MDL:

SMILES:

[Na+].OC1C2OP(=O)([S-])OCC2O[C@H]1n1c(Br)nc2c(=O)[nH]c(N)nc12

Synonym:

sp-8-br-cgmps sodium salt ; guanosine, 8-bromo-,cyclic 3',5'-[hydrogen (s)-phosphorothioate] (9ci) ; 8-bromoguanosine 3',5'-cyclic monophosphothioate, sp-isomer sodium salt ; sp-8-bromoguanosine-3',5'-cyclic monophosphorothioate, sodium salt ; guanosine,8-bromo-, cyclic 3',5'-(hydrogen phosphorothioate), (s)- ; 8-bromoguanosine-3',5'-cyclic monophosphorothioate sodium salt, spisomer ; 8-br-cgmps na, sp-isomer ; 8-bromoguanosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt ; 8-bromoguanosine3,5-cyclicmonophosphothioatesp-isomersodiumsalt,highpurity ; sp-8-br-cgmps ; guanosine 3',5'-cyclic monophosphorothioate, 8-bromo-, sp-isomer, sodium salt ; 8-bromoguanosine-3'',5''-cyclic monophosphothioate sodium salt sp isomer ; 4h-furo[3,2-d]-1,3,2-dioxaphosphorin,guanosine deriv.

Description

Sp-8-Br-cGMPS is a cell-permeable, unspecific activator of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG) 1α. It has been shown to be resistant to cyclic nucleotide phophodiesterases. It is found to be more membrane permeant and lipophilic compare to cyclic GMP.