CFTR Inhibitor-172 | CAS 307510-92-5

Element: inhibitor cftr

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Identification

CFTR Inhibitor-172

CAS:

307510-92-5

EINECS:

Molecular Formula:

C₁₈H₁₀F₃NO₃S₂

MDL:

MFCD06411408

SMILES:

C1=CC(=CC(=C1)N2C(=O)/C(=C/C3=CC=C(C=C3)C(=O)O)/SC2=S)C(F)(F)F

Synonym:

4-[[4-oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid ; cftr inhibitor-172 ; cftrinh 172 (cftr inhibitor-172) ; 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone ; 3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone 4-[(z)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzoic acid ; cftr(inh)-172 ; 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone] ; benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]- ; 4-[4-oxo-2-thioxo-3-(3trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-benzoic acid (for r&d only) ; 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]thiazolidin-

Description

CFTR Inhibitor-172 is a voltage-independent inhibitor of CFTR hloride channel blocker (K_i = 300 nM). CFTR Inhibitor-172 is also shown to block intestinal fluid secretion that is cholera toxin-induced.

Suppliers

Santa Cruz Biotechnology, Inc.

204680

Dayang Chem (Hangzhou) Co.,Ltd.

DC11164464

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CAS equal suppliers

CFTRinh-172

ShangHai Biochempartner Co., Ltd.

BCP15834

CFTR(inh)-172

Ambeed, Inc.

A285038

CFTR(inh)-172

CSNpharm, Inc.

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Aea.ltd

A273546

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Amadis Chemical Company Limited

ACCL12096045

CFTRinh 172; CFTR(inh)-172; CFTR Inhibitor-172

Excenen Pharmatech Co., Ltd.

EX-A2298

Prices & Availability

Data is processed

Properties for CFTR Inhibitor-172

Molecular Weight:

409.4 g·mol−1

Density:

1.61 g/cm³ (Predicted)

Melting point:

254.02° C (Predicted)

Boiling point:

555.71° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (100 mM). Insoluble in water.

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin
R43 - May cause sensitisation by skin contact
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Classes:

irritant

Hazard Symbols:

Xi, N