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Celastrol, Celastrus scandens

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Formula: C29H38O4
CAS: 34157-83-0
search Element: celastrol celastrus scandens
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Identification

Structural Formula
Celastrol, Celastrus scandens
CAS:
34157-83-0
EINECS:
Molecular Formula:
C29H38O4
MDL:
MFCD03424073
SMILES:
CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
Synonym:
celastrol ; tripterin ; tripterine ; celasterol ; celastrol(sh) ; celastrol ,98% ; celastrol (tripterin) ; celastrol(p)(please call) ; 3-hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid ; 2-oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid


Description

Celastrol, Celastrus scandens, a compound originally purified from Tripterygium wilfordii, has been shown to be an anti-peroxidative and anti-angiogenic agent. Mechanistic studies suggest that Celastrol suppresses levels of VEGF and Flk-1 receptors, VEGFR-1 and VEGFR-2, which may reduce signal transduction between the two growth factors. Additionally, Celastrol has demonstrated the ability to disrupt critical interaction of Glu33 (Hsp90) and Arg167 (Cdc37) in the superchaperone complex which causes anti-proliferative activity in vitro and inhibit Topo II (topoisomerase II) activity in vitro (IC50 = 7.41 μM). Celastrol, Celastrus scandens is an inhibitor of Hsp90.


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Alpha Biopharmaceuticals Co., Ltd.
AB29588874
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Santa Cruz Biotechnology, Inc.
202534
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Prices & Availability




Data is processed


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Properties for Celastrol, Celastrus scandens

Molecular Weight:
450.61 g·mol−1
Density:
1.21 g/cm3 (Predicted)
Melting point:
219-230°C
Boiling point:
645.65° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. Insoluble in water.
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Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
Safety Codes:
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Symbols:
T
Hazard symbol T
Storage temperature :
Store at -20°C
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Alternative Distributors of [Celastrol, Celastrus scandens]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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