Chemical-Suppliers Chemical-Suppliers

Caspase-1 inhibitor I

×
Formula: C23H32N4O8
CAS: 143313-51-3
search Element: inhibitor caspase

Identification

Structural Formula
Caspase-1 inhibitor I
CAS:
143313-51-3
EINECS:
Molecular Formula:
C23H32N4O8
MDL:
MFCD00237123
SMILES:
C[C@@H](C(=O)N[C@@H](CC(=O)O)C=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)C
Synonym:
tyr-val-ala-asp-cho ; ice inhibitor i ; ac-yvad-cho ; l-709049 ; caspase inhibitor i ; acetyl-yvad-aldehyde ; yvad-cho ; ice inhibitor ; biotinyl-ac-yvad-cho ; ac-yvad-aldehyde


Description

Caspase-1 Inhibitor I (Ac-YVAD-CHO, also designated L-709049) is a potent, specific, reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Ac-YVAD-CHO has been shown to strongly inhibit anti-APO-1 induced apoptosis in L929-APO-1 cells. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.

Additional caspase-1 inhibitors available:
caspase-1 inhibitor
caspase-1 inhibitor VI
Caspase-1 Inhibitor II (sc-300323)
Caspase-1 Inhibitor IV (sc-300324)


Suppliers

Alfa (A Johnson Matthey Company)
A20166048
Santa Cruz Biotechnology, Inc.
358878
Get Quick Quote

CAS equal suppliers

AC-YVAD-CHO
Alpha Biopharmaceuticals Co., Ltd.
AB3741122
AC-YVAD-CHO
Acinopeptide Co., Ltd.
A242484
Acetyl-tyrosyl-valyl-alanyl-aspartal
Leap Chem Co., Ltd
LC6481944
Acetyl-tyrosyl-valyl-alanyl-aspartal
Finipharma Ltd
F5041008
Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid)
Bachem AG
H-8410.0005

Prices & Availability




Data is processed


x

Properties for Caspase-1 inhibitor I

Molecular Weight:
492.52 g·mol−1
Density:
~1.3 g/cm3 (Predicted)
Melting point:
349.84 °C (Predicted)
Boiling point:
~937.75 °C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (5 mg/ml), water (5 mg/ml) at 25 °C, ethanol (~30 mg/ml), DMF (~30 mg/ml), and PBS(pH 7.2) (~5 mg/ml).
x

Safety & Transport Information

Storage temperature :
-20°C
x

Alternative Distributors of [Caspase-1 inhibitor I]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
x

Downloads

Mol File:
-/-
MSDS:
-/-