ca2+/calmodulin-dependent protein kinase ii (290-309) ; calmodulin dependent protein kinase ii ; cam kinase ii (290-309), calmodulin antagonist ; calmodulin-dependent protein kinase ii (290-309) ; calmodulin binding domain ; 3: pn: us20050158711 seqid: 3 unclaimed sequence ; l-alanine,l-leucyl-l-lysyl-l-lysyl-l-phenylalanyl-l-asparaginyl-l-alanyl-l-arginyl-l-arginyl-l-lysyl-l-leucyl-l-lysylglycyl-l-alanyl-l-isoleucyl-l-leucyl-l-threonyl-l-threonyl-l-methionyl-l-leucyl- ; calmodulin-dependent protein kinase iifr agment 290 ; 35: pn: wo0069900 seqid: 1336unclaimed sequence ; lkkfnarrklkgailttmla ; leu-lys-lys-phe-asn-ala-arg-arg-lys-leu-lys-gly-ala-ile-leu-thr-thr-met-leu-ala ; 1064: pn:us20090175821 seqid: 1336 claimed protein ; cam kinase ii (290-309) ; calmodulin-dependent protein kinase ii fragment 290-309
Description
CaM Kinase II (290-309), Calmodulin Antagonist is a potent, synthetic peptide inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II), which was derived from the cDNA sequence of the rat brain 50-kDa alpha subunit. The use of this inhibitory peptide elucidated the calmodulin binding and inhibitory domains, as well as the initial autophosphorylation site (Thr286) of CaMKII with an IC50 of 52 nM. This peptide product binds CaM (calmodulin) tightly and inhibits additional calmodulin-requiring enzymes, such as PDE (phosphodiesterase) and PP2B (calcineurin). Investigators used this product in STC-1 cells to study the regulation of L-type calcium channels and found the inhibitory peptide to block whole cell calcium currents. Additional research in T84 cells showed that this peptide reduced chloride current by approximately 70% without effect on the channels in parotid acinar cells.
Element: 
Chemical-Suppliers.eu