Calcein-AM | CAS 148504-34-1 | Chemical-Suppliers

Element: calcein

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C-S » Chemicals » calcein-PX71346

Identification

Calcein-AM

CAS:

148504-34-1

EINECS:

Molecular Formula:

C₄₆H₄₆ N₂ O₂₃

MDL:

MFCD05861516

SMILES:

CC(=O)OCOC(=O)CN(CC1=C(C=CC2=C1OC3=C(C24C5=CC=CC=C5C(=O)O4)C=CC(=C3CN(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C)OC(=O)C)OC(=O)C)CC(=O)OCOC(=O)C

Synonym:

spiro[isobenzofuran-1(3h),9'-[9h]xanthene],glycine deriv. ; calcein am ; calcein o,o'-diacetate tetrakis(acetoxymethyl)ester ; nsc 689290 ; calcein-am solution, 1 mmol in dmso* ; glycine,n,n'-[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3h),9'-[9h]xanthene]-2',7'-diyl]bis(methylene)]bis[n-[2-[(acetyloxy)methoxy]-2-oxoethyl]-,bis[(acetyloxy)methyl] ester (9ci) ; calcein am solution ; calcein am, 4mm in anhydrous dmso ; calcein acetoxymethyl ester ; -cellstain-calcein-amsolution ; cal-am ; calcein-am ; calcein-acetoxymethyl ester, diacetate ; glycine,n,n'-[[3',6'-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3h),9'-[9h]xanthene]-2',7'-diyl]bis(methylene)]bis[n-[2-[(acetyloxy)methoxy]-2-oxoethyl]-,1,1'-bis[(acetyloxy)methyl] ester

Description

Calcein-AM is a hydrophobic non-fluorescent probe that can permeate the plasma membrane and can be hydrolyzed to Calcein, which is an extremely fluorescent and negatively charged molecule. The probe can be used to stain living cells and has been observed to fluoresce bright green in cytoplasmic Schwann cells. Calcein-AM has been reported to be a neutral substrate for Mdr (P-glycoprotein (Pgp) and multidrug resistance protein (MRP)) and has been used in flow cytometry studies to analyze the function of P-gp and MRP. Studies suggest that Calcein-AM can be used to detect MDR mediated resistance and to be transported by PGP from the plasma membrane. Mitochondrial permeability research has utilized Calcein as a cytosolic fluorophore. Has been used as a cytosolic fluorophore in mitochondrial permeability studies to image pore transition.