Butyrolactone 3 | CAS 778649-18-6

Element: butyrolactone

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Identification

Butyrolactone 3

CAS:

778649-18-6

EINECS:

Molecular Formula:

C₉H₁₂O₄

MDL:

MFCD08702690

SMILES:

CCC[C@H]1[C@@H](C(=C)C(=O)O1)C(=O)O

Synonym:

butyrolacetone 3 ; butyrolactone 3 ; gcn5 inhibitor 1

Description

Butyrolactone 3, also called MB-3 is an inhibitor of Histone acetyltransferase GCN5 (general control of amino-acid synthesis 5). Gcn5 HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which allows transcription elongation by relaxing nucleosomes. Butyrolactone 3 specifically inhibits Gcn5's HAT activity. It has been shown to display anti-inflammatory and anti-carcinogenic effects.