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t-Butyloxycarbonyl-valyl-citrullyl-4-aminobenzylalcohol

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Formula: C23H37N5O6
CAS: 870487-09-5

Identification

Structural Formula
t-Butyloxycarbonyl-valyl-citrullyl-4-aminobenzylalcohol
CAS:
870487-09-5
EINECS:
Molecular Formula:
C23H37N5O6
MDL:
Synonym:


Description

Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ACD payload will be release only in the cell. Reference: Laurent Ducry (ed.), Antibody-Drug Conjugates, Methods in Molecular Biology, vol. 1045, DOI 10.1007/978-1-62703-541-5_5, # Springer Science+Business Media, LLC 2013.


Suppliers

Iris Biotech GmbH
ADC1020
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Boc-Val-Cit-PAB
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