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t-Butyloxycarbonyl-valyl-citrullyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate

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Formula: C30H40N6O10
CAS: 870487-10-8

Identification

Structural Formula
t-Butyloxycarbonyl-valyl-citrullyl-(4-aminobenzyl)-(4-nitrophenyl)carbonate
CAS:
870487-10-8
EINECS:
Molecular Formula:
C30H40N6O10
MDL:
Synonym:


Description

Linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome the ADC payload will be release only in the cell. Reference: Laurent Ducry (ed.), Antibody-Drug Conjugates, Methods in Molecular Biology, vol. 1045, DOI 10.1007/978-1-62703-541-5_5, # Springer Science+Business Media, LLC 2013.


Suppliers

Iris Biotech GmbH
ADC1010
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CAS equal suppliers

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Amadis Chemical Company Limited
ACCL5892945

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