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BRL-50481

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Formula: C9H12N2O4S
CAS: 433695-36-4
search Element: 50481

Identification

Structural Formula
BRL-50481
CAS:
433695-36-4
EINECS:
Molecular Formula:
C9H12N2O4S
MDL:
MFCD03039912
SMILES:
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C
Synonym:


Description

BRL-50481 is a selective inhibitor of phosphodiesterase 7 (PDE 7) that has acceptable selectivity for in vitro studies. Studies suggest that BRL-50481 is used to inhibit the activity of hrPDE7A1 which is usually expressed in baculovirus-infected Spodoptera frugiperda in a competitive manner. In osteoblasts, BRL-50481increases mineralization and bALP as a result of PDE7 silencing which upregulates several osteogenic genes. Further studies show that BRL-50481increases apoptosis in CLL cells via a mitochondrial-dependent process, and is associated with increased cAMP accumulation and down-regulation of the antiapoptotic protein survivin. BRL-50481 is a inhibitor of PDE7A.


Suppliers

Amadis Chemical Company Limited
ACCL2791395
Santa Cruz Biotechnology, Inc.
201178
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Properties for BRL-50481

Molecular Weight:
244.27 g·mol−1
Density:
~1.3 g/cm3 (Predicted)
Melting point:
141.24° C (Predicted)
Boiling point:
~391.1° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (>40 mg/mL), and ethanol (5 mg/mL). Insoluble in water.
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Alternative Distributors of [BRL-50481]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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