Blasticidin S Hydrochloride, like puromycin, belongs to a group of cytosine amino nucleoside antibiotics. Blasticidin S is isolated from Streptomyces griseochromogenes and inhibits protein synthesis in both prokaryotic and eukaryotic cells, it acts quickly by inhibiting peptide bond formation by the ribosome.
The blasticidin S resistance gene (BSR), found in Bacillus cereus K55-S1, has been used in multiple studies for its use as a selective compound. Resistance is conferred by expression of one of two Blasticidin S deaminase genes: BSD from Aspergillus terreus or bsr from Bacillus cereus. These deaminases convert Blasticidin S to a nontoxic deaminohydroxy derivative.
Solubility.: in water >30 g/l (20°C). In acetic acid >30 g/l (20°C). Practically insoluble in acetone, benzene, carbon tetrachloride, chloroform, cyclohexane, dioxane, ethanol diethyl ether, ethyl acetate, methanol, pyridine, xylene.
Physical Description:
colourless needles
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Safety & Transport Information
Poison by ingestion, skin contact, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See other blastomycin entries.
Risk Codes:
R28 - Very toxic if swallowed
Safety Codes:
S24/25 - Avoid contact with skin and eyes S36/37 - Wear suitable protective clothing and gloves S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(a)
Hazard Symbols:
T+
RID/ADR certification :
3172
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Alternative Distributors of [Blasticidin S Hydrochloride]
Producers or manufacturers change the product range from time to time.
The following companies have appeared as suppliers in the past / currently not verified
Discovery Fine Chemicals Limited | Jinan Haohua Industry Co., Ltd.