Bisbenzimide H 33258 Fluorochrome, Trihydrochloride (H 33258) is a membrane-permeable, adenine-thymine-specific fluorescent stain, that is useful for staining DNA, chromosomes, and nuclei. This product has been shown to bind to the minor groove in DNA and can be used to detect mycoplasma contamination in tissue culture, to indicate early onset of apoptosis, and to sort living cells based on DNA content. H 33258 and the related compound H 33342 have been used in conjunction with RNA aptamers in the 5′ untranslated region (UTR) to control expression of transfected gene constructs, and both have been shown to affect the rate of channel-mediated Ca2+ efflux from junctional cytoplasmic reticulum vesicles; interestingly H 33258 increases eflux while H 33342 decreases it.
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects
Not used
with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization
Safety & Transport Information
Risk Codes:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin R36/38 - Irritating to eyes and skin
Safety Codes:
S23 - Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) S24/25 - Avoid contact with skin and eyes S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36 - Wear suitable protective clothing
Hazard Symbols:
Xn
Storage temperature :
2-8°C
x
Alternative Distributors of [Bisbenzimide H 33258 Fluorochrome, Trihydrochloride]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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