Bis(methylthio)gliotoxin (FR-49175) | CAS 74149-38-5

Element: methylthio gliotoxin 49175

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Identification

Bis(methylthio)gliotoxin (FR-49175)

CAS:

74149-38-5

EINECS:

Molecular Formula:

C₁₅H₂₀N₂O₄S₂

MDL:

MFCD00133146

SMILES:

CN1C(=O)C2(CC3=CC=CC(C3N2C(=O)C1(CO)SC)O)SC

Synonym:

gliotoxin, bis-dethio-bis(methylthio)- ; fr-49175 ; bis(methylthio)gliotoxin (fr-49175) ; 2,3,5aβ,6,10,10a-hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione ; bis(methylthio)gliotoxin ; bis-dethio-bis(methylthio)gliotoxin ; (3r)-2,3,5aβ,6,10,10a-hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione

Description

Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.

Suppliers

Santa Cruz Biotechnology, Inc.

201027

Dayang Chem (Hangzhou) Co.,Ltd.

DC434017360

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Prices & Availability

Data is processed

Properties for Bis(methylthio)gliotoxin (FR-49175)

Molecular Weight:

356.46 g·mol−1

Density:

1.50 g/cm³ (Predicted)

Melting point:

70° C

Boiling point:

669.62° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml), and water (Partly miscible).

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed

Safety Codes:

S36 - Wear suitable protective clothing

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

-20°C

RID/ADR certification :

1544

Alternative Distributors of [Bis(methylthio)gliotoxin (FR-49175)]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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MSDS:

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