Bis(2-mercaptoethyl)sulfone

Bis(2-mercaptoethyl)sulfone (BMS) is a symmetric bisthiol sulfone compound. BMS has been described as a useful compound for the reduction of disulfides in aqueous solutions. Also, BMS is a water-soluble reagent that is useful for the reduction of native disulfide bonds in proteins. It is considered to be a superior reducing agent to DTT. BMS has shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.