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(-)-Bicuculline methobromide

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Formula: C21H20BrNO6
CAS: 73604-30-5
search Element: methobromide bicuculline
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Identification

Structural Formula
(-)-Bicuculline methobromide
CAS:
73604-30-5
EINECS:
Molecular Formula:
C21H20BrNO6
MDL:
SMILES:
C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Br-]
Synonym:
[r-(r,s)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide ; (r-(r*,s*))-5-(6,8-dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq ; (-)-bicuculline 1(s),9(r) methbromide ; bicuculinemethoiodide ; [r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquindinium bromide ; (6r)-6-[(5r)-6,6-dimethyl-7,8-dihydro-5h-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl]-6h-furo[3,2-g][1,3]benzodioxol-7-one bromide ; (-)-bicuculline methobromide ; [r-(r*,s*)]-5-(6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide ; bicuculineracemic


Description

(-)-Bicuculline methobromide is the N-methyl methobromide salt of bicuculline, a competitive antagonist of the GABAA receptor. The N-methyl derivatives (-)-Bicuculline methobromide and (-)-Bicuculline methiodide are more water-soluble and stable than the parent compound and have been employed as specific GABAA receptor antagonists analogous in function to the free base of bicuculline. Non-GABAA-specific behavior divergent from the activity of the parent compound has been reported with (-)-Bicuculline methobromide and (-)-Bicuculline methiodide. Both compounds are observed to block afterhyperpolarizations mediated by Ca2+-activated K+ channels in dopaminergic neurons.


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Santa Cruz Biotechnology, Inc.
200436
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Properties for (-)-Bicuculline methobromide

Molecular Weight:
462.29 g·mol−1
Melting point:
227-230° C
Solubility:
aqueous base: unstable
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Safety & Transport Information

Safety Codes:
S24/25 - Avoid contact with skin and eyes
Hazard Classes:
6.1(b)
Storage temperature :
2-8°C
RID/ADR certification :
UN 1544 6.1 / PG 2
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Alternative Distributors of [(-)-Bicuculline methobromide]

Producers or manufacturers change the product range from time to time. The following companies
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BOC Sciences

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MSDS:
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