1,3-benzenedicarboxamide, n1-[(1s,2r)-3-(cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-n3-[(1r)-1-phenylethyl]- ; n-((1s,2r)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-n'-((r)-1-phenyl-ethyl)-isophthalamide ; 1,3-benzenedicarboxamide, n1-[(1s,2r)-3-(cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-n3-[(1r)-1-phenylethyl]- ; beta-secretase inhibitor iv ; ?-secretase inhibitor iv ; n1-((2s,3r)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-5-(n-methylmethylsulfonamido)-n3-((r)-1-phenylethyl)isophthalamide ; bace-1 inhibitor
Description
β-Secretase Inhibitor IV, a cell-permeable isophthalamide compound containing a hydroxyethylamine motif which binds to BACE-1 active site and potently blocks its proteolytic activity. The compound displays greater selectivity over other aspartyl proteases. β-Secretase Inhibitor IV is an inhibitor of BACE and BACE2.