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17β-hydroxy Wortmannin

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Formula: C23H26O8
CAS: 58053-83-1
search Element: wortmannin hydroxy beta
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Identification

Structural Formula
17β-hydroxy Wortmannin
CAS:
58053-83-1
EINECS:
Molecular Formula:
C23H26O8
MDL:
SMILES:
COC[C@H]1OC(=O)c2coc3C(=O)C4=C([C@H](OC(=O)C)C[C@]5(C)[C@@H](O)CCC45)[C@]1(C)c23
Synonym:


Description

17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds PI 3-kinase and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI 3-kinase and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.


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Santa Cruz Biotechnology, Inc.
358740
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17beta-hydroxy Wortmannin
Santa Cruz Biotechnology, Inc.
sc-358740

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Properties for 17β-hydroxy Wortmannin

Molecular Weight:
430.4 g·mol−1
Density:
1.39 g/cm3 (Predicted)
Melting point:
239.2 °C (Predicted)
Boiling point:
615.4 °C at 760 mmHg (Predicted)
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Alternative Distributors of [17β-hydroxy Wortmannin]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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