1-β-D-Arabinofuranosylcytosine | CAS 147-94-4

Element: arabinofuranosylcytosine beta

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C-S » Chemicals » beta-arabinofuranosylcytosine-PX74813

Identification

1-β-D-Arabinofuranosylcytosine

CAS:

147-94-4

EINECS:

205-705-9

Molecular Formula:

C₉H₁₃N₃O₅

MDL:

MFCD00066487

SMILES:

NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@H](O)C1O

Synonym:

udicil ; ara-c ; citozar ; arabitin ; aracytin ; cytosar ; arafcyt ; erpalfa ; iretin ; nsc63878

Description

1-β-D-Arabinofuranosylcytosine, a cytosine analogue, inhibits DNA polymerases α, δ, and ε, and RNA polymerases resulting in suppression of DNA synthesis and repair. 1-β-D-Arabinofuranosylcytosine acts as an antimetabolic agent which is responsible for damaging DNA during the S-phase of the cell cycle. In addition, 1-β-D-Arabinofuranosylcytosine inhibits nucleotide reductase enzymes that are needed for DNA synthesis to occur. Alternate studies suggest that 1-β-D-Arabinofuranosylcytosine is clastogenic to both spermatogonial cells and bone marrow. Furthermore, 1-β-D-Arabinofuranosylcytosine can be used to control the proliferation of glial cells.

Suppliers

Santa Cruz Biotechnology, Inc.

201628

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Prices & Availability

Data is processed

Properties for 1-β-D-Arabinofuranosylcytosine

Molecular Weight:

243.22 g·mol−1

Density:

1.89 g/cm³ (Predicted)

Melting point:

214 °C

Boiling point:

545.68° C at 760 mmHg (Predicted)

Solubility:

H₂O: 50 mg/mL, clear, colorless

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R43 - May cause sensitisation by skin contact
R63 - Possible risk of harm to the unborn child

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S37/39 - Wear suitable gloves and eye/face protection

Hazard Symbols:

Xn, Xi

Storage temperature :

2-8°C

Alternative Distributors of [1-β-D-Arabinofuranosylcytosine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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