5-Aza-2′-Deoxycytidine | CAS 2353-33-5

Element: deoxycytidine prime

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C-S » Chemicals » aza-deoxycytidine-PX64114

Identification

5-Aza-2′-Deoxycytidine

CAS:

2353-33-5

EINECS:

219-089-4

Molecular Formula:

C₈H₁₂N₄O₄

MDL:

MFCD00043011

SMILES:

NC1=NC(=O)N(C=N1)[C@H]1C[C@@H](O)[C@@H](CO)O1

Synonym:

5-deoxy-2'-azacytidine ; decitabin ; decitabine ; 5-aza-dc ; nsc 127716 ; 2'-deoxy-5-azacytidine ; dacogen ; 5-azadeoxycytidine ; decitabine(nsc127716) ; 5-aza-cdr

Description

5-Aza-2'-Deoxycytidine, has been reported to cause phosphorylation inhibition of 2'-deoxycytidine in certain cells and the incorporation of 2'-deoxycytidine into DNA. Experiments have shown that this compound induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits Dnmt (DNA methyltransferase). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2'-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2.

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Prices & Availability

Data is processed

Properties for 5-Aza-2′-Deoxycytidine

Molecular Weight:

228.21 g·mol−1

Density:

1.91 g/cm³ (Predicted)

Melting point:

~200 °C (dec.)

Boiling point:

485.80° C at 760 mmHg (Predicted)

Solubility:

acetic acid/water (1:1): 50 mg/mL

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R61 - May cause harm to the unborn child
R68 - Possible risk of irreversible effects

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves

Hazard Symbols:

Xn, Xi, T

Storage temperature :

-20°C

Alternative Distributors of [5-Aza-2′-Deoxycytidine]

Producers or manufacturers change the product range from time to time. The following companies
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