Axitinib | CAS 319460-85-0 | Chemical-Suppliers

Element: axitinib

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C-S » Chemicals » axitinib-PX74349

Identification

Axitinib

CAS:

319460-85-0

EINECS:

Molecular Formula:

C₂₂H₁₈N₄OS

MDL:

MFCD09837898

SMILES:

CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

Synonym:

Description

Axitinib is a non-selective receptor kinase inhibitor of Flt and Flk proteins. This compound also inhibits Flt-1(VEGFR-1), Flk-1(VEGFR-2), Flt-4(VEGFR-3), PDGFR-β and c-Kit(c-KIT) with IC₅₀ of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively. Axitinib is studied as an antitumor agent of various cell lines. Axitinib is an inhibitor of PDGFR-β.

Suppliers

H&Z Industry Co.,Ltd

HIC160640

Aea.ltd

A56112

Chemlyte Solutions

CS144432

Ambeed, Inc.

A226761

ZHIWE ChemTech Co Ltd

ZC168504

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI5522208

Shandong Ench Chemical Co.,Ltd

SECC2401200

Hangzhou Cherry Pharmaceutical Technology Co., Ltd.

HCPT4082040

Xiamen Equation Chemical Co.,Ltd

XECC2561280

CSNpharm, Inc.

CSN10361

Hangzhou Lingrui Chemical Co., Ltd.

HLC2801120

Wanko Chemical Co., Ltd.

WC192576

Finetech Industry Limited

FIL200800

Hefei Hirisun Pharmatech Co., Ltd

HR012909

CM Fine Chemicals

CFC136544

AK Scientific, Inc.

AS152456

Simagchem Corporation

SC168504

Xingrui Industry Co., Limited

XIL232928

BOC Sciences

BS96288

Amadis Chemical Company Limited

ACCL2481240

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

217679

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Prices & Availability

Data is processed

Properties for Axitinib

Molecular Weight:

386.47 g·mol−1

Density:

~1.4 g/cm³ (Predicted)

Melting point:

226-228° C

Boiling point:

~668.9° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (42 mg/ml at 25° C), water (<1 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), methanol, and DMF (~0.25 mg/ml).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

GHS09
Environmental hazard

Acute hazards to the aquatic environment, category 1
Chronic hazards to the aquatic environment, categories 1, 2
Environmental toxicity, categories 1, 2

Safety & Transport Information

Alternative Distributors of [Axitinib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified