(+)-Aphidicolin

Tetracyclic diterpene antibiotic with antiviral, antineoplastic and antimitotic properties. It is a reversible inhibitor of eukaryotic nuclear DNA replication and blocks the cell cycle at early S phase. Furthermore it is known as a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses. Aphidicolin belongs to the group of mycotoxins. Origin: Nigrospora oryzae. Spadari, S. et al. Control of cell division by aphidicolin without adverse effects upon resting cells. Arzneimittelforschung. 1985; 35(7):1108-16.