Apelin-13 | CAS 217082-58-1 | Chemical-Suppliers

Element: apelin

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C-S » Chemicals » apelin-PX90094

Identification

Apelin-13

CAS:

217082-58-1

EINECS:

Molecular Formula:

C₆₉H₁₁₁N₂₃O₁₆S

MDL:

MFCD02094627

SMILES:

CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N

Synonym:

65-77-apelin, prepro- ; 17: pn: wo2006076736seqid: 4 claimed sequence ; qrprlshkgpmpf ; gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe ; 65-77-apelin (mus musculus) ; apelin-13 (human, bovine, mouse, rat) ; gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe-oh ; prepro-65-77-apelin ; 17: pn: wo2006023893 seqid: 4 claimed sequence ; apelin-13 (human, bovine) ; apelin-13 trifluoroacetate salt ; l-phenylalanine,l-glutaminyl-l-arginyl-l-prolyl-l-arginyl-l-leucyl-l-seryl-l-histidyl-l-lysylglycyl-l-prolyl-l-methionyl-l-prolyl- ; 15: pn: wo2004081198 seqid: 4 claimedsequence ; 7: pn: wo2005023863 seqid: 7 claimed sequence ; 1: pn: wo2009033784 page: 98 claimed protein ; apelin-13 ; 14: pn:wo2007039184 seqid: 14 claimed sequence ; h-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe-oh ; apelin-13, human, bovine, mouse, rat (2) ; 2: pn:wo2009033819 page: 103 claimed protein

Description

Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is an endogenous ligand of Apelin Receptor (APLNR/APJ receptor), a G protein-coupled receptor (EC₅₀ = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. Apelin-13 is an activator of Apelin Receptor.