Apamin | CAS 24345-16-2 | Chemical-Suppliers

Element: apamin

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C-S » Chemicals » apamin-PX65604

Identification

Apamin

CAS:

24345-16-2

EINECS:

246-182-7

Molecular Formula:

C₇₉H₁₃₁ N₃₁ O₂₄ S₄

MDL:

MFCD00167944

SMILES:

C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)N)C(=O)N1)CC(C)C)C)[C@@H](C)O)CCC(=O)O)C)CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC4=CN=CN4)C(=O)N)CCCNC(=N)N)CCCNC(=N)N

Synonym:

cnckapetalcarrcqqh-nh2 (disulfide bridge: 1-11,3-15) ; apamin (reduced), cyclic (1? ; apamin (honey bee, apis melifera) ; 15)-bis(disulfide) ; apamin (honeybee, apis mellifera) ; 66: pn: wo2008088422 figure: 8 claimed protein ; cnckapetalcarrcqqh-nh2 ; apamin, bee venom ; apamin ; apamin from bee venom ; apamine ; l-histidinamide,l-cysteinyl-l-asparaginyl-l-cysteinyl-l-lysyl-l-alanyl-l-prolyl-l-a-glutamyl-l-threonyl-l-alanyl-l-leucyl-l-cysteinyl-l-alanyl-l-arginyl-l-arginyl-l-cysteinyl-l-glutaminyl-l-glutaminyl-,cyclic (1? ; apamin from honey bee venom ; m.w. 2027.34 c79h131n31o24s4 ; 68: pn:wo2006116156 seqid: 68 claimed protein

Description

Apamin: Caution! Highly toxic. Handle with care. The smallest neurotoxin known. It is the only polypeptide neurotoxin that is known to pass the blood-brain barrier. Comprises about 2% by weight of the dried venom of the honey bee. It is a potent (1-10 nM) and highly selective inhibitor of the SK (low conductance Ca²⁺-activated K⁺ channel). Acts on the central nervous system. SK channel blockers such as apamin can have therapeutic applications, for example on the peripheral cells (e.g. the insulin releasing cells of the pancreas) and on the central nervous system where there is evidence for a role of SK channels in memory processes, both general and specifically hippocampal.

Suppliers

Bachem AG

H-8010.0500

Acinopeptide Co., Ltd.

A132264

Iris Biotech GmbH

LS-1280.0000

Leap Chem Co., Ltd

LC108324

Santa Cruz Biotechnology, Inc.

200994

Dayang Chem (Hangzhou) Co.,Ltd.

DC186744

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CAS equal suppliers

H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2

Salsbury Chemicals, Inc.

SC18485544

Bee venom: [Cys1-Cys11, Cys3-Cys15] H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2

Iris Biotech GmbH

LS-1280

Prices & Availability

Data is processed

Properties for Apamin

Molecular Weight:

2027.65 g·mol−1

Density:

1.63

Solubility:

0.05 M acetic acid: 5 mg/mL, clear, colorless to faintly yellow

Safety & Transport Information

Poison by intravenous, parenteral, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of SOx and NOx.

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes

Hazard Classes:

6.1(b)

Storage temperature :

-20°C

RID/ADR certification :

2811

Alternative Distributors of [Apamin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

-/-

MSDS:

-/-

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Apamin;CNCKAPETALCARRCQQH-NH2(Disulfidebridge:1-11:3-15)