Antibiotic A-23187, 4-Bromo | CAS 76455-82-8

Element: antibiotic 23187 bromo

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C-S » Chemicals » antibiotic-bromo-PX66361

Identification

Antibiotic A-23187, 4-Bromo

CAS:

76455-82-8

EINECS:

Molecular Formula:

C₂₉H₃₆ Br N₃ O₆

MDL:

SMILES:

CC1CCC2(C(CC(C(O2)C(C)C(=O)C3=CC=CN3)C)C)OC1CC4=NC5=C(C(=C(C=C5O4)Br)NC)C(=O)O

Synonym:

4-Benzoxazolecarboxylicacid,2-[[8-[2-(4-bromo-1H-pyrrol-2-yl)-1-methyl-2-oxoethyl]-3,9,11-trimethyl-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-5-(methylamino)-,[6S-[6a(2S*,3S*),8b(R*),9b,11a]]- ; 1,7-Dioxaspiro[5.5]undecane, 4-benzoxazolecarboxylic acid deriv. ; 23-Bromo-A-23187 ; Br-A 23187 ; 4-Benzoxazolecarboxylicacid,2-[[(2R,3R,6S,8S,9R,11R)-8-[(1S)-2-(4-bromo-1H-pyrrol-2-yl)-1-methyl-2-oxoethyl]-3,9,11-trimethyl-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-5-(methylamino)-,[6S-[6a(2S*,3S*),8b(R*),9b,11a]]- (9CI)

Description

Antibiotic A-23187, 4-Bromo is a divalent cation-specific, ionophoretic antibiotic that acts as a channel for cations such as Mn²⁺, Ca²⁺, and Mg²⁺. In addition, this antibiotic is produced by Streptomyces chartreusensis to combat against gram-positive bacteria. Studies suggest that A-23187, 4-Bromo is widely used to increase intracellular free Ca2+ concentration in cells. Furthermore, A-23187, 4-Bromo promotes the equilibration of [Ca²⁺] gradients between cellular compartments, including the ER, mitochondria and cytosol. In axons, a modest mitochondrial depolarization is amplified in the presence of A-23187 and is suppressed in the absence of extracellular Ca²⁺.

Suppliers

Santa Cruz Biotechnology, Inc.

200193

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CAS equal suppliers

4-Br-A23187

Iris Biotech GmbH

LS-1001.0000

4-Bromo-A23187

Iris Biotech GmbH

LS-1001

4-Bromo-A23187

Santa Cruz Biotechnology, Inc.

SCB4201680

4-Bromo-calcium-ionophore

Haihang Industry Co., Ltd.

HI6501950

4-Bromo-beta-1,beta-1,beta-1,2,3,5,6-heptafluorotoluene

Haihang Industry Co., Ltd.

HI572017160

Prices & Availability

Data is processed

Properties for Antibiotic A-23187, 4-Bromo

Molecular Weight:

602.52 g·mol−1

Density:

1.43 g/cm³

Melting point:

96°C

Boiling point:

747.4°C at 760 mmHg

Flash point:

405.8°C

Solubility:

Soluble in methanol or methylene chloride. Insoluble in water

Physical Description:

yellow solid

Safety & Transport Information

Risk Codes:

R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Symbols:

Alternative Distributors of [Antibiotic A-23187, 4-Bromo]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH

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MSDS:

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