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Amprenavir

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Formula: C25H35N3O6S
CAS: 161814-49-9
search Element: amprenavir

Identification

Structural Formula
Amprenavir
CAS:
161814-49-9
EINECS:
Molecular Formula:
C25H35N3O6S
MDL:
MFCD00934214
SMILES:
CC(C)(C)N(C[C@@H](O)[C@H](CC1=CC=CC=C1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)C1=CC=C(N)C=C1
Synonym:
vx 478 ; prozei ; 141w94, kvx-478, agenerase, prozei, ; angenerase ; agenerase ; amprenavir(kvx-478) ; kvx-478 ; amprenavir ; 141w94 ; amprenavir(agenerase)


Description

Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ± 12.5 ng/ml for wild-type HIV isolates. Like all HIV protease inhibitors, amprenavir interrupts the maturation phase of the HIV replicative cycle by forming an inhibitor-enzyme complex, which prevents HIV protease from binding with its normal substrates. This compound has an enzyme inhibition constant (Ki = 0.6 nM) that falls within the Ki range of the other protease inhibitors. Amprenavir is an inhibitor of HIV-1 Protease.


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Aozeal Certified Standards (AOCS), Inc.
A0019.00
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6902760
Aea.ltd
A70140
Chemlyte Solutions
CS180540
Alpha Biopharmaceuticals Co., Ltd.
AB3401020
Xiamen Equation Chemical Co.,Ltd
XECC3201600
CSNpharm, Inc.
CSN16717
Hangzhou Lingrui Chemical Co., Ltd.
HLC3501400
scienTEST - bioKEMIX GmbH
S-B2501000
AK Scientific, Inc.
AS190570
Leap Chem Co., Ltd
LC180540
Santa Cruz Biotechnology, Inc.
207287
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Properties for Amprenavir

Molecular Weight:
505.63 g·mol−1
Density:
~1.3 g/cm3 (Predicted)
Melting point:
72-74 °C
Solubility:
Soluble in DMSO (16 mg/ml at 25° C), chloroform, dichloromethane, ethanol (101 mg/ml at 25° C), and water (partly).