5-Aminosalicylic acid | CAS 89-57-6

Element: aminosalicylic acid

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C-S » Chemicals » aminosalicylic-acid-PX69771

Identification

5-Aminosalicylic acid

CAS:

89-57-6

EINECS:

201-919-1

Molecular Formula:

C₇H₇NO₃

MDL:

MFCD00007877

SMILES:

NC1=CC(C(O)=O)=C(O)C=C1

Synonym:

mesasal ; 5-as ; pentasa ; canasa ; 5-asa ; asalit ; asacol ; ipocol ; rowasa ; lixacol

Description

5-Aminosalicylic Acid, the metabolite of sulphasalazine, has been shown to inhibit PGDH (prostaglandin 15-hydroxydehydrogenase) in human placenta and bovine lung. Further studies show that this antiinflammatory compound also inhibits leukotriene formation in human leukocytes. Additionally, 5-Aminosalicylic acid demonstrates the ability to disrupt TNFα (tumor necrosis factor α)-stimulated NFκB (nuclear factor κB) activation via inhibition of the multimeric IκB kinase regulating complex.

Suppliers

H&Z Industry Co.,Ltd

HIC8403360

Krada CPS Industry S.L

KCIS9244620

Wuhan PharmChem Co., LTD.

WP10503150

Shandong SanYoung Industry Co., Ltd

SSI14705880

Chemlyte Solutions

CS7562268

Autech Industry Co.,Limited

AIC11344536

Shandong Minglang Chemical Co., Ltd

SMC14705880

Indofine Chemical Co, Inc.

06-1374

Xiamen Equation Chemical Co.,Ltd

XECC13446720

Hainan Zhongxin Chemical Co., Ltd.

HZC14285712

Daming Changda Co., Ltd.

DC10083024

Aecochem Corp.

AC5881764

CSNpharm, Inc.

CSN13074

Hangzhou Keying Chem Co., Ltd.

HKC12605040

Sigma-Aldrich International GmbH

SI13444032

scienTEST - bioKEMIX GmbH

S-B10504200

Finetech Industry Limited

FIL10504200

Carbone Scientific Co., Ltd.

CS11763528

Hefei Hirisun Pharmatech Co., Ltd

HR130609

AK Scientific, Inc.

AS7982394

Simagchem Corporation

SC8822646

Xingrui Industry Co., Limited

XIL12184872

Leap Chem Co., Ltd

LC7562268

Santa Cruz Biotechnology, Inc.

202890

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Prices & Availability

Data is processed

Properties for 5-Aminosalicylic acid

Molecular Weight:

153.14 g·mol−1

Density:

1.57 g/cm³

Melting point:

275-280 °C (dec.)(lit.)

Boiling point:

403.86° C at 760 mmHg (Predicted)

Flash point:

279-281 °C

Solubility:

Soluble in 1 M hydrochloric acid (50 mg/ml), water (0.84 g/l at 20° C), alcohol, DMSO (~4 mg/ml), DMF (~1.6 mg/ml), PBS(pH=7.2) (~1.7 mg/ml), methanol, water (1.7 mg/ml at 25° C), and ethanol (31 mg/ml at 25° C). Insoluble in diethyl ether, and n-octanol.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Classes:

irritant

Hazard Symbols:

Storage temperature :

2-8°C

Alternative Distributors of [5-Aminosalicylic acid]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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