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4-Amino-1,8-naphthalimide

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Formula: C12H8N2O2
CAS: 1742-95-6
search Element: naphthalimide amino
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Identification

Structural Formula
4-Amino-1,8-naphthalimide
CAS:
1742-95-6
EINECS:
217-110-1
Molecular Formula:
C12H8N2O2
MDL:
MFCD00006921
SMILES:
C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N
Synonym:
4-ani ; dfp1 ; 4-amino-1,8-naphthalimide ; 4-aminonaphthalimide ; 4-amino-1,8-naphthalimide 98% ; 4-amino-naphthalimid ; 4-aminonaphthalene-1,8-dicarbimide ; 4-amino-1,8-naphthalimide,98% ; 4-amino-1,8-naphthalenedicarbimide ; timtec-bb sbb003425


Description

4-Amino-1,8-naphthalimide is a small molecule inhibitor of PARP-1 (poly (ADP-ribose) polymerase-1), an enzyme responsible for mediating covalent attachment of residues to proteins. Inhibition of this enzyme can sensitize cells to the cytotoxicity of chemical agents, and can also decrease cell death related to reperfusion and ischemia-related oxygen free radicals by attenuating the rapid depletion of cellular NAD and ATP resulting from excessive activation of PARP.


Suppliers

JieJie Group Co., Ltd.
JG11003300
+
Santa Cruz Biotechnology, Inc.
200125
Dayang Chem (Hangzhou) Co.,Ltd.
DC15506200
+
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HI14044212

Prices & Availability




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Properties for 4-Amino-1,8-naphthalimide

Molecular Weight:
212.2 g·mol−1
Density:
1.105 g/mL at 25 °C(lit.)
Melting point:
360 °C
Boiling point:
~544.07 °C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (5 mg/ml).
Physical Description:
orange amorphous powder
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S37/39 - Wear suitable gloves and eye/face protection
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
-20°C
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Alternative Distributors of [4-Amino-1,8-naphthalimide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Acros Organics BVBA | Suzhou Rovathin Pharmatech Co., Ltd | Jinan Haohua Industry Co., Ltd.

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