[3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid]

A potent, reversible, highly selective Inhibitor for acid proteases (aspartate proteases). Has shown to inhibit HIV and MMTV proteases and no activity against thiol proteases. Pepstatin is little toxic. Potential targets: Pepsin, Renin, Cathepsin D, Chymosin, Protease B, retroviral Proteases References: T. Munkhjargal, M. AbouLaila, M. A. Terkawi, T. Sivakumar, M. Ichikawa, B. Davaasuren, T. Nyamjargal, N. Yokoyama, and I. Igarashi(2012) Inhibitory Effects of Pepstatin A and Mefloquine on the Growth of Babesia Parasites. Am. J. Trop. Med. Hyg., 87(4), 681-688. H. Umezawa, T. Aoyagi, H. Morishima, M. Matsuzaki, M. Hamada. (1970) Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo), 23(5), 259­62.