D-Amino Acid Oxidase Inhibitor is a cell-permeable thienopyrrole compound that potently inhibits cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively). Exhibits no activity towards D-aspartate oxidase (DDO; IC50 >5 µM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 µM), and a panel of over 150 other enzymes, receptors, and ion channels. Although treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects
Not used
with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization
Safety & Transport Information
Risk Codes:
R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Symbols:
Xn, Xi
x
Alternative Distributors of [D-Amino Acid Oxidase Inhibitor]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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