Amiloride, 5-(N,N-Dimethyl)-, hydrochloride

Amiloride, 5-(N,N-Dimethyl)-, hydrochloride (DMA) is an inhibitor of the Na⁺-H⁺ exchanger (NHE) with stronger potency than the parent compound, amiloride. DMA and other amiloride derivatives have been employed in elucidating the dynamics and activity of the NHE. Inhibition of the NHE by DMA was demonstrated to protect against severe ischemia/reperfusion-induced cardiac contractile dysfunction by normalizing tissue Na⁺ levels and preserving contractile function recovery during reperfusion.