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Alsterpaullone

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Formula: C16H11N3O3
CAS: 237430-03-4
search Element: alsterpaullone
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Identification

Structural Formula
Alsterpaullone
CAS:
237430-03-4
EINECS:
Molecular Formula:
C16H11N3O3
MDL:
MFCD02683579
SMILES:
C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]
Synonym:
9-nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one ; alsterpaullone ; 9-nitro-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5h)-one ; 9-nitropaullone ; 9-nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5h)-one ; nsc 705701


Description

Alsterpaullone is a potent ATP-competitive and cell cycle cyclin-dependent kinase inhibitor, that is reported to be the most active Paullone. The paullones belong to a family of benzazepinones, and are described to highly inhibit neuronal CDK5/p25 and glycogen synthase kinase-3β (GSK-3β). Studies report that Alsterpaullone activates caspase-9 and enhances apoptosis in Jurkat cells, inhibits CDK5/p25-dependent phosphorylation of DARPP-32 in in vitro mouse striatum slices, and blocks the phosphorylation of Tau by GSK-3β.


Suppliers

Helpsyn Chemical Co., Ltd
HC3501050
BOC Sciences
BS168504
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Amadis Chemical Company Limited
ACCL4342170
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Leap Chem Co., Ltd
LC252756
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Santa Cruz Biotechnology, Inc.
202453
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Prices & Availability




Data is processed


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Properties for Alsterpaullone

Molecular Weight:
293.28 g·mol−1
Density:
1.46 g/cm3 (Predicted)
Melting point:
>330°C
Boiling point:
651.53° C at 760 mmHg (Predicted)
Solubility:
DMSO: soluble
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
2-8°C
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Alternative Distributors of [Alsterpaullone]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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