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20α-Hydroxy Cholesterol

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Formula: C27H46O2
CAS: 516-72-3
search Element: cholesterol hydroxy alpha
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Identification

Structural Formula
20α-Hydroxy Cholesterol
CAS:
516-72-3
EINECS:
Molecular Formula:
C27H46O2
MDL:
MFCD16661190
SMILES:
CC(C)CCC[C@@](C)(O)C1CCC2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C
Synonym:
20-hydroxycholesterol ; c05500 ; 20[s]-hydroxycholesterol ; 5-cholestene-3b,20a-diol ; 5-cholestene-3β,20α-diol ; 20a-hydroxycholesterol ; cholest-5-ene-3,20a-diol ; (3)-cholest-5-ene-3,20-diol ; cholest-5-ene-3β,20-diol ; 20alpha-hydroxycholesterol


Description

20α-Hydroxy Cholesterol is an allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that binds at a site distinct from the canonical cyclopamine binding site. 20α-Hydroxy Cholesterol activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). It induces Smo accumulation in primary cilia and also exhibits osteogenic activity and activates the liver X receptor (LXR).


Suppliers

Santa Cruz Biotechnology, Inc.
209393
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CAS equal suppliers

20a-Hydroxy Cholesterol
Santa Cruz Biotechnology, Inc.
sc-209393
20a-Hydroxy Cholesterol
Sigma-Aldrich International GmbH
SI14724416

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Properties for 20α-Hydroxy Cholesterol

Molecular Weight:
402.65 g·mol−1
Melting point:
136-137 °C
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Safety & Transport Information

Storage temperature :
-20 °C Freezer
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Alternative Distributors of [20α-Hydroxy Cholesterol]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | Clearsynth Canada INC.

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Downloads

Mol File:
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MSDS:
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