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N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-trityl-L-threonine

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Formula: C38H33NO5
CAS: 133180-01-5
search Element: fluorenylmethyloxycarbonyl threonine trityl alpha
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Identification

Structural Formula
N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-trityl-L-threonine
CAS:
133180-01-5
EINECS:
Molecular Formula:
C38H33NO5
MDL:
MFCD00237034
Synonym:
n-alpha-(9-fluorenylmethoxycarbonyl)-o-trityl-l-threonine ; fmoc-thr(trt)-oh fmoc-o-trityl-l-threonine ; n-(9-fluorenylmethyloxycarbonyl)-o-trityl-l-threonine ; n-alpha-fmoc-o-trityl-l-threonine ; fmoc-l-thr(trt)-oh ; fmoc-o-trityl-l-threonine ; trityl-l-threonine ; fmoc-thr(trt)-oh ; fmoc-thr(trt) ; fmoc-thr(trt)-oh 99%


Description

The Trt group can be removed with 1% TFA in dichloromethane (silanes as scavengers) while tBu-type protecting groups stay intact. Resin bound Hse(Trt), Ser(Trt), Thr(Trt), and Tyr(Clt) are versatile building blocks for on-resin side chain modifications, like phosphorylation, sulfonation or PEGylation. References: 1. Preparation and application of N-Fmoc-O-Trt-hydroxy amino acids for solid-phase synthesis of peptides; K.Barlos, D.Gatos, S.Koutsogianni, W.Schafer, G.Stavropoulos, Y.Wenqing; Tetrahedron Lett. 1991; 32(4): 471-474. 2. Fmoc/Trt-amino acids: comparison to Fmoc/tBu-amino acids in peptide synthesis; K.Barlos, D.Gatos, S.Koutsogianni; J. Pept. Res. 1998; 51(3): 194-200.


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Prices & Availability




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Properties for N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-trityl-L-threonine

Molecular Weight:
583.67 g·mol−1
Melting point:
68-77°C
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-trityl-L-threonine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ABCR GmbH & Co. KG

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