N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic acid alpha-(2-phenylisopropyl ester)

A Glutamic acid building block with free side chain and PP protected alpha-carboxylic acid function. The 2-phenylisopropyl protecting group can be deprotected with 1% TFA in dichloromethane. PP protected amino acids are also less prone towards aspartamide formation. References: C.Yue et al.; Tetrahedron Lett. 1993; 34: 323. F.Dick et al.; Peptides 1996; Proceedings of the 24th European Peptide Symposium Edinborough, Scotland, p.339. R.Ramage, R.Epton, eds. Mayflower Scientific Ltd., England (1998) M.Mergler et al.; J.Pept.Sci. 2003; 9: 36. S.M.Ocampo et al.; Org.Lett. 2005; 7: 4349.