N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-proline | CAS 1982344-79-5

Element: fluorenylmethyloxycarbonyl dimethyl proline alpha beta beta

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C-S » Chemicals » alpha-fluorenylmethyloxycarbonyl-beta-beta-dimethyl-proline-PX1830675

Identification

N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-proline

CAS:

1982344-79-5

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Description

beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. Reference: Benzyl 2-Cyano-3,3-Dimethyl-1-pyrrolidinecarboxylate, a Versatile Intermediate for the Synthesis of 3,3-Dimethylproline Derivatives; Jesus R. Medina, Charles W. Blackledge, Karl F. Erhard, Jeffrey M. Axten, and William H. Miller; J. Org. Chem. 2008; 73: 3946-3949. DOI: 10.1021/jo7027163.

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