N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-glutamic acid gamma-t-butyl ester

Element: fluorenylmethyloxycarbonyl dimethyl glutamic alpha butyl ester gamma acid beta beta

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C-S » Chemicals » alpha-fluorenylmethyloxycarbonyl-beta-beta-dimethyl-glutamic-acid-gamma-butyl-ester-PX2567551

Identification

N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-glutamic acid gamma-t-butyl ester

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Description

beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. Reference: Synthesis of beta,beta-Dimethylated Amino Acid Building Blocks Utilizing the 9-Phenylfluorenyl Protecting Group; N. Kawahata, M. Weisberg, M. Goodman; J. Org. Chem. 1999; 64: 4362-4369.