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N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-aspartic acid beta-t-butyl ester

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Formula: C25H29NO6
CAS: 1392219-11-2

Identification

Structural Formula
N-alpha-(9-Fluorenylmethyloxycarbonyl)-beta,beta-dimethyl-L-aspartic acid beta-t-butyl ester
CAS:
1392219-11-2
EINECS:
Molecular Formula:
C25H29NO6
MDL:
Synonym:


Description

beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. Reference: Synthesis of beta,beta-Dimethylated Amino Acid Building Blocks Utilizing the 9-Phenylfluorenyl Protecting Group; N. Kawahata, M. Weisberg, M. Goodman; J. Org. Chem. 1999; 64: 4362-4369. Development of an Intein-Inspired Amide Cleavage Chemical Device; C. Komiya, K. Aihara, K. Morishita, H. Ding, T. Inokuma, A. Shigenaga and A. Otaka; The Journal of Organic Chemistry 2016; 81: 699-707. doi:10.1021/acs.joc.5b02399


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