N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester

Element: fluorenylmethyloxycarbonyl aspartic allyl alpha ester acid beta

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C-S » Chemicals » alpha-fluorenylmethyloxycarbonyl-aspartic-acid-beta-allyl-ester-PX442606

Identification

N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester

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Description

Building block with side protection orthogonal to Fmoc/tBu strategy. Can be used for side specific derivatization, for example for TFA mediated in situ cyclization, which is taking advantage of intermediate aspartamide formation. Reference: A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage; Koushik Chandra, Tapta Kanchan Roy, Deborah E. Shalev, Abraham Loyter, Chaim Gilon, R. Benny Gerber, and Assaf Friedler; Angew. Chem. Int. Ed. 2014; 53: 9450-9455. DOI: 10.1002/anie.201402789.