Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond. Furthermore Dmb and Tmb amino acids prevent aggregation during solid phase synthesis and can prevent aspartimide formation when it is introduced before an Asp residue. They can also increase peptide cyclization efficiency. Standard coupling protocols can be applied with reagents such as PyBOP, DIC/HOBt or HATU. Acidic deprotection methods used with Wang resin generate the native sequence. References: Johnson, T. et al. J. Peptide Sci. 1995; 1: 11. Clausen, N. et al. in 'Peptide: Chemistry, Structure and Biology', Kaumaya, P.T.P. and Hodges, R.S. (Eds.), Mayflower Scientific Ltd., 1995; 71. Jauch, K. et al. in 'Peptide 1996: Proceeding of the 24th EPS', Ramage, R. and Epton, R. (Eds.), Mayflower Scientific Ltd., 1996; 497. El Haddadi, M. et al. J. Peptide Sci. 2000; 6: 560. Zahariev, S. et al. J. Peptide Sci. 2005; 11: 17.
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