1α,25-Dihydroxyvitamin D3 | CAS 32222-06-3

Element: dihydroxyvitamin alpha

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C-S » Chemicals » alpha-dihydroxyvitamin-PX82228

Identification

1α,25-Dihydroxyvitamin D3

CAS:

32222-06-3

EINECS:

250-963-8

Molecular Formula:

C₂₇H₄₄O₃

MDL:

MFCD00867079

SMILES:

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CCC/C2=CC=C/3C[C@H](C[C@@H](C3=C)O)O)C

Synonym:

toptriol ; soltriol ; panbonis ; silkis ; topitriol ; ro215535 ; 1,25-dhcc ; rocaltrol ; calcitrol ; calcijex

Description

1α,25-Dihydroxyvitamin D₃ (Calcitriol) is a metabolite of the secosteroid vitamin D₃. This hormone stimulates intestinal calcium transport at a much higher rate than vitamin D₃ and hydroxy D₃, and is considered to represent the biologically active form of vitamin D₃. In addition to regulating the movement of calcium in the blood and bone, 1α,25-Dihydroxyvitamin D₃ participates in developmental regulation and signaling. It stimulates an increase in protein kinase C levels with an effect on the regulation of c-myc transcription and activation of Raf kinase. 1α,25-Dihydroxyvitamin D₃ is shown to increase the synthesis of prostacyclin with a correlated increase in cyclooxygenase activity, indicating a further role in vascular regulation. 1α,25-Dihydroxyvitamin D3 (Calcitriol) is an activator of PKC and VDR.

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Santa Cruz Biotechnology, Inc.

202877

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BLD Pharmatech Ltd

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Hangzhou MolCore BioPharmatech Co.,Ltd.

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Prices & Availability

Data is processed

Properties for 1α,25-Dihydroxyvitamin D3

Molecular Weight:

416.64 g·mol−1

Density:

~1.1 g/cm³ (Predicted)

Melting point:

119-1210C

Boiling point:

~565.01° C at 760 mmHg (Predicted)

Flash point:

14 °C

Solubility:

Chloroform, DMSO, Ethanol, Ethyl Acetate, Methanol, Tetrahydrofuran,

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R63 - Possible risk of harm to the unborn child

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S7 - Keep container tightly closed

Hazard Classes:

6.1(a)

Hazard Symbols:

T+, Xn, F

Storage temperature :

2-8°C

RID/ADR certification :

UN 2811 6.1 / PG 1

Alternative Distributors of [1α,25-Dihydroxyvitamin D3]

Producers or manufacturers change the product range from time to time. The following companies
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