N-alpha-t-Butyloxycarbonyl-N-epsilon-[1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl]-L-lysine | CAS 862847-44-7

Element: butyloxycarbonyl dioxocyclohex methylbutyl dimethyl epsilon ylidene lysine alpha

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C-S » Chemicals » alpha-butyloxycarbonyl-epsilon-dimethyl-dioxocyclohex-ylidene-methylbutyl-lysine-PX2567008

Identification

N-alpha-t-Butyloxycarbonyl-N-epsilon-[1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl]-L-lysine

CAS:

862847-44-7

EINECS:

Molecular Formula:

C₂₄H₄₀N₂O₆

MDL:

Synonym:

Description

Building block with side protection orthogonal to Fmoc/tBu strategy. Can be used for side specific derivatization, for example for TFA mediated in situ cyclization, which is taking advantage of intermediate aspartamide formation. Reference: A Tandem In Situ Peptide Cyclization through Trifluoroacetic Acid Cleavage; Koushik Chandra, Tapta Kanchan Roy, Deborah E. Shalev, Abraham Loyter, Chaim Gilon, R. Benny Gerber, and Assaf Friedler; Angew. Chem. Int. Ed. 2014; 53: 9450-9455. DOI: 10.1002/anie.201402789.